LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.

ABSTRACT: mRNAs are key molecules in gene expression and subject to diverse regulatory events. Regulation is accomplished by distinct sets of trans-acting factors that interact with mRNAs and form defined mRNA-protein complexes (mRNPs). The resulting "mRNP code" determines the fate of any given mRNA and thus controlling gene expression at the post-transcriptional level. The La-related protein 4B (LARP4B) belongs to an evolutionarily conserved family of RNA-binding proteins characterized by the presence of a La-module implicated in direct RNA binding. Biochemical experiments have shown previously direct interactions of LARP4B with factors of the translation machinery. This finding along with the observation of an association with actively translating ribosomes suggested that LARP4B is a factor contri

SUBMITTER: Kuspert M 

PROVIDER: S-EPMC4478348 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature