The Drosophila melanogaster Mutants apblot and apXasta Affect an Essential apterous Wing Enhancer.

ABSTRACT: The selector gene apterous (ap) plays a key role during the development of the Drosophila melanogaster wing because it governs the establishment of the dorsal-ventral (D-V) compartment boundary. The D-V compartment boundary is known to serve as an important signaling center that is essential for the growth of the wing. The role of Ap and its downstream effectors have been studied extensively. However, very little is known about the transcriptional regulation of ap during wing disc development. In this study, we present a first characterization of an essential wing-specific ap enhancer. First, we defined an 874-bp fragment about 10 kb upstream of the ap transcription start that faithfully recapitulates the expression pattern of ap in the wing imaginal disc. Analysis of deletions in the ap l

SUBMITTER: Bieli D 

PROVIDER: S-EPMC4478543 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature