Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment.

ABSTRACT: Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney transplantation and influences short term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, chronic rejection and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that result in a distinct inflammatory reaction of the kidney graft. Underlying factors of ischemia reperfusion include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necroptosis. Chemokines and cytokines together with other fact

SUBMITTER: Salvadori M 

PROVIDER: S-EPMC4478600 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature