P-selectin is a host receptor for Plasmodium MSP7 ligands.

ABSTRACT:

Background

Plasmodium parasites typically elicit a non-sterile but protective immune response in human host populations, suggesting that the parasites actively modulate normal immunological mechanisms. P-selectin is a cell surface receptor expressed in mammals, that is a known component of the inflammatory response against pathogens and has been previously identified as a host factor that influences malaria-associated pathology both in human patients and rodent infection models.

Methods

To better understand the molecular mechanisms underlying the involvement of P-selectin in the pathogenesis of malaria, a systematic extracellular protein interaction screen was used to identify Plasmodium falciparum merozoite surface protein 7 (MSP7) as a binding partner of human P-selectin.

SUBMITTER: Perrin AJ 

PROVIDER: S-EPMC4478713 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature