Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat Diet.

ABSTRACT:

Background

Relations of the 25 mammalian selenoprotein genes with obesity and the associated inflammation remain unclear.

Objective

This study explored impacts of high-fat diet-induced obesity on inflammation and expressions of selenoprotein and obesity-related genes in 10 tissues of pigs.

Methods

Plasma and 10 tissues were collected from pigs (n = 10) fed a corn-soy-based control diet or that diet containing 3-7% lard from weanling to finishing (180 d). Plasma concentrations (n = 8) of cytokines and thyroid hormones and tissue mRNA abundance (n = 4) of 25 selenoprotein genes and 16 obesity-related genes were compared between the pigs fed the control and high-fat diets. Stepwise regression was applied to analyze correlations among all these measures, including the pre

SUBMITTER: Zhao H 

PROVIDER: S-EPMC4478952 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature