A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.

ABSTRACT:

Objective

The trigeminovascular system plays a central role in migraine, a condition in need of new treatments. The neuropeptide, calcitonin gene-related peptide (CGRP), is proposed as causative in migraine and is the subject of intensive drug discovery efforts. This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system.

Methods

Receptor expression was determined using Taqman G protein-coupled receptor arrays and immunohistochemistry in trigeminal ganglia (TG) and the spinal trigeminal complex of the brainstem in rat and human. Receptor pharmacology was quantified using sensitive signaling assays in primary rat TG neurons.

Results

mRNA and histological expression analysis in rat and human samples revealed the

SUBMITTER: Walker CS 

PROVIDER: S-EPMC4479521 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature