Schizophrenia-like topological changes in the structural connectome of individuals with subclinical psychotic experiences.

ABSTRACT: Schizophrenia is often regarded as a "dysconnectivity" disorder and recent work using graph theory has been used to better characterize dysconnectivity of the structural connectome in schizophrenia. However, there are still little data on the topology of connectomes in less severe forms of the condition. Such analysis will identify topological markers of less severe disease states and provide potential predictors of further disease development. Individuals with psychotic experiences (PEs) were identified from a population-based cohort without relying on participants presenting to clinical services. Such individuals have an increased risk of developing clinically significant psychosis. 123 individuals with PEs and 125 controls were scanned with diffusion-weighted MRI. Whole-brain structural

SUBMITTER: Drakesmith M 

PROVIDER: S-EPMC4479544 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature