CD15 Expression Does Not Identify a Phenotypically or Genetically Distinct Glioblastoma Population.

ABSTRACT:

Unlabelled

: Recent research has focused on the hypothesis that the growth and regeneration of glioblastoma (GB) is sustained by a subpopulation of self-renewing stem-like cells. This has led to the prediction that molecular markers for cancer stem cells in GB may provide a treatment target. One candidate marker is CD15: we wanted to determine if CD15 represented a credible stem cell marker in GB. We first demonstrated that CD15-positive (CD15+) cells were less proliferative than their CD15-negative (CD15-) counterparts in 10 patient GB tumors. Next we compared the proliferative activity of CD15+ and CD15- cells in vitro using tumor-initiating primary GB cell lines (TICs) and found no difference in proliferative behavior. Furthermore, TICs sorted for CD15+ and CD15- were not signif

SUBMITTER: Kenney-Herbert E 

PROVIDER: S-EPMC4479614 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature