Comparison of Acute Health Effects From Exposures to Diesel and Biodiesel Fuel Emissions.

ABSTRACT:

Objective

To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions.

Methods

We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting-lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidative stress were assessed.

Results

B75 reduced respirable diesel particulate matter by 20%. Lung function declined significantly more after exposure to diesel emissions. Lung inflammatory cells along with sputum and plasma inflammatory mediators increased significantly to similar levels with both exposures. Urinary 8-hydroxydeoxyguanosine, a marker of oxidative stress, was not sign

SUBMITTER: Mehus AA 

PROVIDER: S-EPMC4479787 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature