Effect Size Estimates for the ESCAPE Trial: Proportional Odds Regression Versus Other Statistical Methods.

ABSTRACT:

Background and purpose

Ordinal outcomes, such as modified Rankin Scale (mRS), are the standard primary end points in acute stroke trials. Regression models for assessing treatment efficacy after adjusting for baseline covariates have been developed for continuous, binary, or ordinal end points. There has been no consensus on the best choice of method for analyzing these data.

Methods

We compared several regression models for assessing treatment efficacy in acute stroke trials using existing data sets from the Interventional Management of Stroke-III and Prolyse in Acute Cerebral Thromboembolism II (PROACT-2) trials. Patients with baseline non-contrast computed tomographic Alberta Stroke Program Early CT Score (ASPECTS) > 5, baseline computed tomographic angiography, or conven

SUBMITTER: Sajobi TT 

PROVIDER: S-EPMC4479971 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature