From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions.

ABSTRACT: We present the case of a 68-year-old man admitted to hospital with severe acute kidney injury secondary to statin-induced rhabdomyolysis. Five weeks previously, the patient started a course of clarithromycin for infection of a finger wound with Mycobacterium marinum. His current medications included simvastatin, which he continued along with clarithromycin. The severity of the acute kidney injury necessitated initial continuous venovenous haemofiltration followed by 12 haemodialysis sessions before a spontaneous improvement in renal function occurred. Statins are widely prescribed and we report this case to encourage increased vigilance in avoiding drug interactions known to increase the risk of statin-induced myopathy, including macrolide antibiotics, calcium channel antagonists and amiod

SUBMITTER: Hill FJ 

PROVIDER: S-EPMC4480123 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature