Stroke Induces Nuclear Shuttling of Histone Deacetylase 4.

ABSTRACT:

Background and purpose

Histone deacetylases (HDACs) 4 and 5 are abundantly expressed in the brain and have been implicated in the regulation of neurodegeneration. Under physiological conditions, HDACs 4 and 5 are expressed in the cytoplasm of brain cells where they cannot directly access chromatin. In response to external stimuli, they can shuttle to the nucleus and regulate gene expression. However, the effect of stroke on nuclear shuttling of HDACs 4 and 5 remains unknown.

Methods

Using a rat model of middle cerebral artery occlusion, we examined the subcellular localization of HDACs 4 and 5 in the peri-infarct cortex during brain repair after stroke.

Results

Stroke significantly increased nuclear HDAC4 immunoreactivity in neurons, but not in astrocytes or in oligod

SUBMITTER: Kassis H 

PROVIDER: S-EPMC4480163 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature