Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets.

ABSTRACT: The main purpose of this work was to identify a set of AIMs that stratify the genetic structure and diversity of the Thai population from a high-throughput autosomal genome-wide association study. In this study, more than one million SNPs from the international HapMap database and the Thai depression genome-wide association study have been examined to identify ancestry informative markers (AIMs) that distinguish between Thai populations. An efficient strategy is proposed to identify and characterize such SNPs and to test high-resolution SNP data from international HapMap populations. The best AIMs are identified to stratify the population and to infer genetic ancestry structure. A total of 124 AIMs were clearly clustered geographically across the continent, whereas only 89 AIMs stratified

SUBMITTER: Vongpaisarnsin K 

PROVIDER: S-EPMC4480199 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature