NET-GE: a novel NETwork-based Gene Enrichment for detecting biological processes associated to Mendelian diseases.

ABSTRACT:

Background

Enrichment analysis is a widely applied procedure for shedding light on the molecular mechanisms and functions at the basis of phenotypes, for enlarging the dataset of possibly related genes/proteins and for helping interpretation and prioritization of newly determined variations. Several standard and Network-based enrichment methods are available. Both approaches rely on the annotations that characterize the genes/proteins included in the input set; network based ones also include in different ways physical and functional relationships among different genes or proteins that can be extracted from the available biological networks of interactions.

Results

Here we describe a novel procedure based on the extraction from the STRING interactome of sub-networks connecti

SUBMITTER: Di Lena P 

PROVIDER: S-EPMC4480278 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature