Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

ABSTRACT: Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity in which the T cells that are present are quantitatively or functionally deficient. Impaired humoral immunity is also common. Patients have severe infections, autoimmunity, or both. The specific molecular, cellular, and clinical features of many types of combined immunodeficiencies remain unknown. Methods We performed genetic and cellular immunologic studies involving five unrelated children with early-onset invasive bacterial and viral infections, lymphopenia, and defective T-cell, B-cell, and natural killer (NK)-cell responses. Two patients died early in childhood; after allogeneic hematopoietic stem-cell transplantation, the other three had normalization of T-cell function and clinical improvement. Res

SUBMITTER: Dobbs K 

PROVIDER: S-EPMC4480434 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature