YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence.

ABSTRACT: Attempts to identify biomarkers to detect prostate tumorigenesis, and thus minimize prostate cancer progression and inform treatment decisions have primarily focused on alterations at the DNA and mRNA levels, ignoring alterations at the level of protein synthesis control. We have previously shown that the PI3K-AKT-mTOR pathway, frequently deregulated in prostate cancer, specifically induces the synthesis of proteins that contribute to metastasis, most notably YB-1 and MTA1, without altering mRNA levels thereby demonstrating the importance of translation control in driving the expression of these genes in cancer.Here, we analyze genomic sequencing and mRNA expression databases, as well as protein expression employing an annotated tissue microarray generated from 332 prostate cancer patients

SUBMITTER: Sheridan CM 

PROVIDER: S-EPMC4480693 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature