Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.

ABSTRACT: As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels t

SUBMITTER: Lualdi M 

PROVIDER: S-EPMC4480721 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature