Ontology highlight
ABSTRACT:
SUBMITTER: Briest F
PROVIDER: S-EPMC4480744 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Oncotarget 20150401 10
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogeneous tumors that need to be molecularly defined to obtain novel therapeutic options. Forkheadbox protein M1 (FOXM1) is a crucial transcription factor in neoplastic cells and has been associated with differentiation and proliferation. We found that FOXM1 is strongly associated with tumor differentiation and occurrence of metastases in gastrointestinal NENs. In vitro inhibition by the FOXM1 inhibitor siomycin A led to down-reg ...[more]