Widespread intron retention diversifies most cancer transcriptomes.

ABSTRACT:

Background

Somatic mutations affecting components of the RNA splicing machinery occur with high frequencies across many tumor types. These mutations give rise to distinct alterations in normal splice site and exon recognition, such as unusual 3' splice site preferences, that likely contribute to tumorigenesis.

Methods

We analyzed genome-wide patterns of RNA splicing across 805 matched tumor and normal control samples from 16 distinct cancer types to identify signals of abnormal cancer-associated splicing.

Results

We found that abnormal RNA splicing, typified by widespread intron retention, is common across cancers even in the absence of mutations directly affecting the RNA splicing machinery. Almost all liquid and solid cancer types exhibited frequent retention of bot

SUBMITTER: Dvinge H 

PROVIDER: S-EPMC4480902 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature