Alternative matrices for therapeutic drug monitoring of immunosuppressive agents using LC-MS/MS.

ABSTRACT: Immunosuppressive drugs used in solid organ transplants typically have narrow therapeutic windows and high intra- and intersubject variability. To ensure satisfactory exposure, therapeutic drug monitoring (TDM) plays a pivotal role in any successful posttransplant maintenance therapy. Currently, recommendations for optimum immunosuppressant concentrations are based on blood/plasma measurements. However, they introduce many disadvantages, including poor prediction of allograft survival and toxicity, a weak correlation with drug concentrations at the site of action and the invasive nature of the sample collection. Thus, alternative matrices have been investigated. This paper reviews tandem-mass spectrometry (LC-MS/MS) methods used for the quantification of immunosuppressant drugs utilizing n

SUBMITTER: Ghareeb M 

PROVIDER: S-EPMC4480919 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature