Associations of Sleep Apnea, NRG1 Polymorphisms, Alcohol Consumption, and Cerebral White Matter Hyperintensities: Analysis with Genome-Wide Association Data.

ABSTRACT:

Study objective

There are few studies on gene-environment interactions with obstructive sleep apnea (OSA). Our study aimed to explore genetic polymorphisms associated with OSA using genome-wide association (GWA) data and evaluate the effects of relevant polymorphisms on the association between risk factors, including obesity and alcohol consumption, and OSA. We also investigated on these associations in relation to cerebral white matter hyperintensities (WMH) on magnetic resonance images.

Design

A cross-sectional design.

Setting

A polysomnography study embedded in a population-based cohort from the Korean Genome Epidemiology Study was conducted in 2011-2013.

Participants

1,763 participants aged 48-78 years.

Results

251 individuals were identified to have

SUBMITTER: Baik I 

PROVIDER: S-EPMC4481000 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature