Transcranial Assessment and Visualization of Acoustic Cavitation: Modeling and Experimental Validation.

ABSTRACT: The interaction of ultrasonically-controlled microbubble oscillations with tissues and biological media has been shown to induce a wide range of bioeffects that may have significant impact on therapy and diagnosis of brain diseases and disorders. However, the inherently non-linear microbubble oscillations combined with the micrometer and microsecond scales involved in these interactions and the limited methods to assess and visualize them transcranially hinder both their optimal use and translation to the clinics. To overcome these challenges, we present a framework that combines numerical simulations with multimodality imaging to assess and visualize the microbubble oscillations transcranially. In the present work, microbubble oscillations were studied with an integrated US and MR imaging

SUBMITTER: Arvanitis CD 

PROVIDER: S-EPMC4481181 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature