Out-of-sync: disrupted neural activity in emotional circuitry during film viewing in melancholic depression.

ABSTRACT: While a rich body of research in controlled experiments has established changes in the neural circuitry of emotion in major depressive disorders, little is known as to how such alterations might translate into complex, naturalistic settings--namely involving dynamic multimodal stimuli with rich contexts, such as those provided by films. Neuroimaging paradigms employing dynamic natural stimuli alleviate the anxiety often associated with complex tasks and eschew the need for laboratory-style abstractions, hence providing an ecologically valid means of elucidating neural underpinnings of neuropsychiatric disorders. To probe the neurobiological signature of refined depression subtypes, we acquired functional neuroimaging data in patients with the melancholic subtype of major depressive disorde

SUBMITTER: Guo CC 

PROVIDER: S-EPMC4481375 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature