Physical Features of Intracellular Proteins that Moonlight on the Cell Surface.

ABSTRACT: Moonlighting proteins comprise a subset of multifunctional proteins that perform two or more biochemical functions that are not due to gene fusions, multiple splice variants, proteolytic fragments, or promiscuous enzyme activities. The project described herein focuses on a sub-set of moonlighting proteins that have a canonical biochemical function inside the cell and perform a second biochemical function on the cell surface in at least one species. The goal of this project is to consider the biophysical features of these moonlighting proteins to determine whether they have shared characteristics or defining features that might suggest why these particular proteins were adopted for a second function on the cell surface, or if these proteins resemble typical intracellular proteins. The latte

SUBMITTER: Amblee V 

PROVIDER: S-EPMC4481411 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature