A major role of insulin in promoting obesity-associated adipose tissue inflammation.

ABSTRACT:

Objective

Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulation of its receptor on target tissues. Here we tested the novel hypothesis that insulin also impairs systemic insulin sensitivity by specifically enhancing adipose inflammation.

Methods

Circulating insulin levels were reduced by about 50% in diet-induced and genetically obese mice by treatments with diazoxide or streptozotocin, respectively. We then examined AT crown-like structures, macrophage markers and pro-inflammatory cytokine expression in AT. AT lipogenesis and systemic insulin sensitivity was also monitored. Conversely, insu

SUBMITTER: Pedersen DJ 

PROVIDER: S-EPMC4481426 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature