Antibiotic Restriction Might Facilitate the Emergence of Multi-drug Resistance.

ABSTRACT: High antibiotic resistance frequencies have become a major public health issue. The decrease in new antibiotics' production, combined with increasing frequencies of multi-drug resistant (MDR) bacteria, cause substantial limitations in treatment options for some bacterial infections. To diminish overall resistance, and especially the occurrence of bacteria that are resistant to all antibiotics, certain drugs are deliberately scarcely used--mainly when other options are exhausted. We use a mathematical model to explore the efficiency of such antibiotic restrictions. We assume two commonly used drugs and one restricted drug. The model is examined for the mixing strategy of antibiotic prescription, in which one of the drugs is randomly assigned to each incoming patient. Data obtained from Rabi

SUBMITTER: Obolski U 

PROVIDER: S-EPMC4481510 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature