Inherited genetic variation in childhood acute lymphoblastic leukemia.

ABSTRACT: Although somatically acquired genomic alterations have long been recognized as the hallmarks of acute lymphoblastic leukemia (ALL), the last decade has shown that inherited genetic variations (germline) are important determinants of interpatient variability in ALL susceptibility, drug response, and toxicities of ALL therapy. In particular, unbiased genome-wide association studies have identified germline variants strongly associated with the predisposition to ALL in children, providing novel insight into the mechanisms of leukemogenesis and evidence for complex interactions between inherited and acquired genetic variations in ALL. Similar genome-wide approaches have also discovered novel germline genetic risk factors that independently influence ALL prognosis and those that strongly modify

SUBMITTER: Moriyama T 

PROVIDER: S-EPMC4481591 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature