Dynamic Visual Display of Treatment Response in HIV-Infected Adults.

ABSTRACT:

Background

Using a dynamic visual display, we examine the changes in human immunodeficiency virus type 1 (HIV-1) plasma viral load and CD4 cell count for 5 years after antiretroviral therapy initiation in a large cohort of patients with HIV.

Methods

Patients at a Centers for AIDS Research Network of Integrated Clinical Systems site who initiated combination antiretroviral therapy between 1 January 2000 and 31 December 2012 were followed for 5 years for HIV-1 plasma viral load, CD4 cell count, and mortality. The joint distribution of CD4 cell count and viral load over time was depicted in an animated display using a bivariate kernel smoother.

Results

Within days of therapy initiation, many patients had a suppressed viral load and their median CD4 cell count had increas

SUBMITTER: Edwards JK 

PROVIDER: S-EPMC4481601 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature