Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland.

ABSTRACT:

Background

We investigated whether children with a higher respiratory syncytial virus (RSV) genomic load are at a higher risk of more-severe bronchiolitis.

Methods

Two multicenter prospective cohort studies in the United States and Finland used the same protocol to enroll children aged <2 years hospitalized for bronchiolitis and collect nasopharyngeal aspirates. By using real-time polymerase chain reaction analysis, patients were classified into 3 genomic load status groups: low, intermediate, and high. Outcome measures were a length of hospital stay (LOS) of ≥3 days and intensive care use, defined as admission to the intensive care unit or use of mechanical ventilation.

Results

Of 2615 enrolled children, 1764 (67%) had RSV bronchiolitis. Children with a low genomic l

SUBMITTER: Hasegawa K 

PROVIDER: S-EPMC4481613 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature