Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients.

ABSTRACT:

Background

An association between GB virus C (GBV-C) and improved outcomes of human immunodeficiency virus (HIV) infection has been reported in HIV-positive individuals with active GBV-C coinfection. This study provides insights into the immune mechanisms underlying the protective role of GBV-C in HIV-infected patients.

Methods

The concentrations of 64 cytokines and chemokines were measured in plasma samples obtained from the Viral Activation Transfusion Study cohort before transfusion and longitudinally from 30 patients positive for both HIV and GBV-C (hereafter, "cases") and 30 patients positive for HIV and negative for GBV-C (hereafter, "controls").

Results

Cases had lower HIV viral loads and higher CD4 T-cell counts than controls after acquisition of GBV-C infecti

SUBMITTER: Lanteri MC 

PROVIDER: S-EPMC4481614 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature