RepExplore: addressing technical replicate variance in proteomics and metabolomics data analysis.

ABSTRACT:

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High-throughput omics datasets often contain technical replicates included to account for technical sources of noise in the measurement process. Although summarizing these replicate measurements by using robust averages may help to reduce the influence of noise on downstream data analysis, the information on the variance across the replicate measurements is lost in the averaging process and therefore typically disregarded in subsequent statistical analyses.We introduce RepExplore, a web-service dedicated to exploit the information captured in the technical replicate variance to provide more reliable and informative differential expression and abundance statistics for omics datasets. The software builds on previously published statistical methods, which have been applied

SUBMITTER: Glaab E 

PROVIDER: S-EPMC4481852 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature