An event-driven approach for studying gene block evolution in bacteria.

ABSTRACT:

Motivation

Gene blocks are genes co-located on the chromosome. In many cases, gene blocks are conserved between bacterial species, sometimes as operons, when genes are co-transcribed. The conservation is rarely absolute: gene loss, gain, duplication, block splitting and block fusion are frequently observed. An open question in bacterial molecular evolution is that of the formation and breakup of gene blocks, for which several models have been proposed. These models, however, are not generally applicable to all types of gene blocks, and consequently cannot be used to broadly compare and study gene block evolution. To address this problem, we introduce an event-based method for tracking gene block evolution in bacteria.

Results

We show here that the evolution of gene blocks in

SUBMITTER: Ream DC 

PROVIDER: S-EPMC4481853 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature