Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

ABSTRACT:

Purpose

Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for external beam PBI. Relative to external beam delivery, alternative PBI techniques require equipment that is not universally available. To address these issues, we designed a phase 1 trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response.

Methods and materials

Women aged ≥55 years with clinically node-negative, estrogen receptor-positive, and/or pro

SUBMITTER: Horton JK 

PROVIDER: S-EPMC4481883 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature