Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference.

ABSTRACT:

Objective

To conduct an epigenome-wide analysis of DNA methylation and obesity traits.

Methods

DNA methylation was quantified in CD4+ T-cells using the Illumina Infinium HumanMethylation450 array in 991 participants of the Genetics of Lipid Lowering Drugs and Diet Network. Methylation at individual cytosine-phosphate-guanine (CpG) sites as a function of body mass index (BMI) and waist circumference (WC), adjusting for age, gender, study site, T-cell purity, smoking, and family structure, was modeled.

Results

Epigenome-wide significant associations between eight CpG sites and BMI and five CpG sites and WC, successfully replicating the top hits in whole blood samples from the Framingham Heart Study (n = 2,377) and the Atherosclerosis Risk in Communities study (n = 2,097

SUBMITTER: Aslibekyan S 

PROVIDER: S-EPMC4482015 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature