Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.

ABSTRACT:

Background

There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes.

Methods

Case-control and cohort studies published before March 2015 were searched through PubMed and Embase. Two authors independently extracted data and scored the study quality according to the Newcastle-0ttawa Scale. The pooled ORs and 95%CI were estimated using the random-effects model and heterogeneity was assessed by the Q test and I2 statistic.

Results

A total of 20 studies were finally included. The results provided no evidence of the association between prenatal alcohol expo

SUBMITTER: Yang J 

PROVIDER: S-EPMC4482023 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature