Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands.

ABSTRACT: We report the synthesis, characterization, and antiproliferative activity of 15 iridium(III) half-sandwich complexes of the type [(η⁵-Cp*)Ir(2-(R'-phenyl)-R-pyridine)Cl] bearing either an electron-donating (-OH, -CH₂OH, -CH₃) or electron-withdrawing (-F, -CHO, -NO₂) group at various positions on the 2-phenylpyridine (2-PhPy) chelating ligand giving rise to six sets of structural isomers. The X-ray crystal structures of [(η⁵-Cp*)Ir(2-(2'-fluorophenyl)pyridine)Cl] (1) and [(η⁵-Cp*)Ir(2-(4'-fluorophenyl)pyridine)Cl] (2) exhibit the expected "piano-stool" configuration. DFT calculations showed that substituents caused only localized effects on the electrostatic potential surface of the chelating 2-PhPy ligand of th

SUBMITTER: Millett AJ 

PROVIDER: S-EPMC4482135 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature