APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.

ABSTRACT:

Background

The frequencies of apolipoprotein L1 (APOL1) variants and their associations with chronic kidney disease (CKD) vary substantially in populations from Africa. Moreover, available studies have used very small sample sizes to provide reliable estimates of the frequencies of these variants in the general population. We determined the frequency of the two APOL1 risk alleles (G1 and G2) and investigated their association with renal traits in a relatively large sample of mixed-ancestry South Africans. APOL1 risk variants (G1: rs60910145 and rs73885319; G2: rs71785313) were genotyped in 859 African mixed ancestry individuals using allele-specific TaqMan technology. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Disease (MDRD) and Chronic

SUBMITTER: Matsha TE 

PROVIDER: S-EPMC4482162 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature