Core oxidative stress response in Aspergillus nidulans.

ABSTRACT:

Background

The b-Zip transcription factor AtfA plays a key role in regulating stress responses in the filamentous fungus Aspergillus nidulans. To identify the core regulons of AtfA, we examined genome-wide expression changes caused by various stresses in the presence/absence of AtfA using A. nidulans microarrays. We also intended to address the intriguing question regarding the existence of core environmental stress response in this important model eukaryote.

Results

Examination of the genome wide expression changes caused by five different oxidative stress conditions in wild type and the atfA null mutant has identified a significant number of stereotypically regulated genes (Core Oxidative Stress Response genes). The deletion of atfA increased the oxidative stress sensitivi

SUBMITTER: Emri T 

PROVIDER: S-EPMC4482186 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature