The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency.

ABSTRACT:

Introduction

The worldwide shortage of donor livers has prompted the search for alternative cell therapies. Previous data from our laboratory proved a supportive role for stem cell therapy in the treatment of end-stage liver disease patients. Therefore; this study was conducted to assess the clinical and biochemical effects of repeated stem cell infusion.

Methods

Ninety patients with liver cirrhosis were randomized to receive either one session treatment (G-I) or two sessions 4 months apart (G-II) of autologous haematopoietic stem cells (HSCs) transplantation and a control group (G-III) who received regular liver treatment. G-CSF was administered to transplanted patients before infusion; HSCs were isolated from 400 cc bone marrow (BM) aspirate. CD34+/CD133+ cells were purifi

SUBMITTER: Zekri AR 

PROVIDER: S-EPMC4482193 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature