A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins.

ABSTRACT:

Background

Polybasic cleavage sites of the hemagglutinin (HA) proteins are considered to be the most important determinants indicating virulence of the avian influenza viruses (AIV). However, evidence is accumulating that these sites alone are not sufficient to establish high pathogenicity. There need to exist other sites located on the HA protein outside the cleavage site or on the other proteins expressed by AIV that contribute to the pathogenicity.

Results

We employed rule-based computational modeling to construct a map, with high statistical significance, of amino acid (AA) residues associated to pathogenicity in 11 proteins of the H5 type viruses. We found potential markers of pathogenicity in all of the 11 proteins expressed by the H5 type of AIV. AA mutations S-43(HA1

SUBMITTER: Khaliq Z 

PROVIDER: S-EPMC4482282 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature