Changes in Neurofilament and Microtubule Distribution following Focal Axon Compression.

ABSTRACT: Although a number of cytoskeletal derangements have been described in the setting of traumatic axonal injury (TAI), little is known of early structural changes that may serve to initiate a cascade of further axonal degeneration. Recent work by the authors has examined conformational changes in cytoskeletal constituents of neuronal axons undergoing traumatic axonal injury (TAI) following focal compression through confocal imaging data taken in vitro and in situ. The present study uses electron microscopy to understand and quantify in vitro alterations in the ultrastructural composition of microtubules and neurofilaments within neuronal axons of rats following focal compression. Standard transmission electron microscopy processing methods are used to identify microtubules, while neurofilamen

SUBMITTER: Fournier AJ 

PROVIDER: S-EPMC4482325 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature