Reward-Induced Phasic Dopamine Release in the Monkey Ventral Striatum and Putamen.

ABSTRACT: In-vivo voltammetry has successfully been used to detect dopamine release in rodent brains, but its application to monkeys has been limited. We have previously detected dopamine release in the caudate of behaving Japanese monkeys using diamond microelectrodes (Yoshimi 2011); however it is not known whether the release pattern is the same in various areas of the forebrain. Recent studies have suggested variations in the dopaminergic projections to forebrain areas. In the present study, we attempted simultaneous recording at two locations in the striatum, using fast-scan cyclic voltammetry (FSCV) on carbon fibers, which has been widely used in rodents. Responses to unpredicted food and liquid rewards were detected repeatedly. The response to the liquid reward after conditioned stimuli was en

SUBMITTER: Yoshimi K 

PROVIDER: S-EPMC4482386 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature