Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila.

ABSTRACT: Mechanotransduction of tension can govern the remodeling of cardiomyocytes during growth or cardiomyopathy. Tension is signaled through the integrin adhesion complexes found at muscle insertions and costameres but the relative importance of signalling during cardiomyocyte growth versus remodelling has not been assessed. Employing the Drosophila cardiomyocyte as a genetically amenable model, we depleted the levels of Talin, a central component of the integrin adhesion complex, at different stages of heart growth and remodeling. We demonstrate a continuous requirement for Talin during heart growth to maintain the one-to-one apposition of myofibril ends between cardiomyocytes. Retracted myofibrils cannot regenerate appositions to adjacent cells after restoration of normal Talin expression, an

SUBMITTER: Bogatan S 

PROVIDER: S-EPMC4482443 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature