Water Channels Aquaporin 4 and -1 Expression in Subependymoma Depends on the Localization of the Tumors.

ABSTRACT:

Background

We analyzed aquaporin 4 and -1 expression in subependymomas, benign and slow growing brain tumors WHO grade I. Ten subependymoma cases were investigated, five of the fossa inferior and five of the fossa superior.

Methods and results

Using immunohistochemistry, we observed different aquaporin expression patterns depending on localization: aquaporin 4 and -1 were detected in infratentorial subependymomas in the entire tumor tissue. In contrast, supratentorial subependymomas revealed aquaporin 4 and -1 expression only in border areas of the tumor. PCR analyses however showed no difference in aquaporin 4 expression between all subependymomas independent of localization but at higher levels than in normal brain. In contrast, aquaporin 1 RNA levels were found to be high

SUBMITTER: Noell S 

PROVIDER: S-EPMC4482577 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature