Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children.

ABSTRACT:

Background

Several infectious diseases and therapeutic interventions cause gut microbe dysbiosis and associated pathology. We characterised the gut microbiome of children exposed to the helminth Schistosoma haematobium pre- and post-treatment with the drug praziquantel (PZQ), with the aim to compare the gut microbiome structure (abundance and diversity) in schistosome infected vs. uninfected children.

Methods

Stool DNA from 139 children aged six months to 13 years old; with S. haematobium infection prevalence of 27.34% was extracted at baseline. 12 weeks following antihelminthic treatment with praziqunatel, stool DNA was collected from 62 of the 139 children. The 16S rRNA genes were sequenced from the baseline and post-treatment samples and the sequence data, clustered into

SUBMITTER: Kay GL 

PROVIDER: S-EPMC4482744 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature