Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses.

ABSTRACT: α- and β-neurexins are presynaptic cell-adhesion molecules whose general importance for synaptic transmission is well documented. The specific functions of neurexins, however, remain largely unknown because no conditional neurexin knockouts are available and targeting all α- and β-neurexins produced by a particular gene is challenging. Using newly generated constitutive and conditional knockout mice that target all neurexin-3α and neurexin-3β isoforms, we found that neurexin-3 was differentially required for distinct synaptic functions in different brain regions. Specifically, we found that, in cultured neurons and acute slices of the hippocampus, extracellular sequences of presynaptic neurexin-3 mediated trans-synaptic regulation of postsynaptic AMPA receptors. In cultured neurons and acu

SUBMITTER: Aoto J 

PROVIDER: S-EPMC4482778 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature