Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.

ABSTRACT: The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tu

SUBMITTER: Godlewski J 

PROVIDER: S-EPMC4482852 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature