The long-term risk of malignant astrocytic tumors after structural brain injury--a nationwide cohort study.

ABSTRACT:

Background

Neoplastic transformation of damaged astrocytes has been proposed as a possible pathological mechanism behind malignant astrocytic tumors. This study investigated the association between structural brain injuries causing reactive astrogliosis and long-term risk for malignant astrocytic tumors.

Methods

The cohort consisted of all individuals living in Denmark between 1978 and 2011. The personal identification number assigned to all individuals allowed retrieval of diagnoses of traumatic brain injury, cerebral ischemic infarction, and intracerebral hemorrhage from the National Patient Discharge Register. Diagnoses of anaplastic astrocytoma and glioblastoma multiforme (World Health Organization grades III and IV) were retrieved from the Danish Cancer Registry. Rate r

SUBMITTER: Munch TN 

PROVIDER: S-EPMC4482857 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature