Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria.

ABSTRACT:

Background

Although diffuse intrinsic pontine glioma (DIPG) carries the worst prognosis of all pediatric brain tumors, studies on prognostic factors in DIPG are sparse. To control for confounding variables in DIPG studies, which generally include relatively small patient numbers, a survival prediction tool is needed.

Methods

A multicenter retrospective cohort study was performed in the Netherlands, the UK, and Germany with central review of clinical data and MRI scans of children with DIPG. Cox proportional hazards with backward regression was used to select prognostic variables (P < .05) to predict the accumulated 12-month risk of death. These predictors were transformed into a practical risk score. The model's performance was validated by bootstrapping techniques.

Resul

SUBMITTER: Jansen MH 

PROVIDER: S-EPMC4483042 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature