TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas.

ABSTRACT:

Background

Activating somatic mutations in the promoter region of the telomerase reverse transcriptase gene (TERT) have been detected in several cancers. In this study we investigated the TERT promoter mutations and their impact on patient survival in World Health Organization grade IV glioblastoma multiforme (GBM).

Methods

The TERT core promoter region containing the previously described mutations and a common functional polymorphism (rs2853669) was sequenced in tumors and blood samples from 192 GBM patients. O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation status was assessed by pyrosequencing in 177 (92.2%) cases. Relevant clinical data were obtained from a prospectively maintained electronic database.

Results

We detected specific (-124 C>T and

SUBMITTER: Simon M 

PROVIDER: S-EPMC4483052 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature